What is clobetasol propionate

Clobetasol propionate is the most potent synthetic glucocorticosteroid for local use on the skin. Applied locally on the skin, 0.05% concentration of the ointment has very strong anti-inflammatory, antipruritic, anti-allergic, and vasoconstrictor action. It exhibits lipophilic properties and easily permeates to organism through the skin.

Ingredients included in clobetasol

• cetostearyl alcohol, which can cause local skin reactions (for example, contact dermatitis).

• propylene glycol, which can cause skin irritation.

• methylparaben, which can cause allergic reactions (possibly delayed) and extremely rarely, bronchospasm.

• propylparaben, which can cause similar reactions as methylparaben

What is clobetasol propionate 0.05 used for

• often recurrent eczema

• psoriasis (thickened areas of inflamed, reddened skin, often covered with silvery scales), with the exception of extensive plaque psoriasis.

• lichen planus

• discoid lupus erythematosus

• dermatitis and other skin diseases that are not sensitive to the action of weaker steroid creams or ointments.

• focal alopecia

An interesting fact about clobetasol propionate cream 0.05%

Concentration used for hair loss in children named “focal alopecia”.(P) A randomized blind comparative study on the efficacy and safety of 0.05% clobetasol propionate cream and 1% hydrocortisone cream with focal alopecia in 42 children aged 2 to 16 years was made in Toronto (Canada). The preparations were applied to the areas of hair loss with a thin layer 2 times a day for two six-week cycles with a six-week break between them.

After 24-week monitoring, it was concluded that the effect of clobetasol propionate cream significantly higher than 1% hydrocortisone cream with a practically identical safety profile in both creams. The level of cortisol in the urine at the beginning and end of the observation did not change. The authors recommend 0.05% clobetasol propionate cream as an effective and safe drug as a topical first-line remedy for limited forms of focal alopecia in children.

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What do you have to know before using clobetasol

Do not take clobetasol if you have these problems

• If you have the allergic reaction to clobetasol propionate or any other component of the drug.

• Children under 1-year-old

If you have the following dermatological pathologies, as it may worsen the situation

• Acne

• Rosacea

• spotted red rash around the mouth (perioral dermatitis)

• anal and genital pruritus

• itchy skin, not accompanied by inflammation

• extensive plaque psoriasis, except in cases with single lesions.

The precautions for clobetasol propionate

Clobetasol is recommended for short-term use. If necessary, you can conduct repeated short treatment courses. Avoid getting the cream (ointment) in the eyes (possibly increasing intraocular pressure). Before applying the skin should be cleaned. If you will have any doubts or questions, it is better to talk with an expert in pharmacology or your doctor.

The storage of clobetasol

Keep out of reach of children, cool, protected from moisture and sun rays place.

Shelf life – 3 years. Do not take clobetasol beyond the expiration date printed on the package.

Do not flush medications into wastewater or into sewers. Ask your doctor how to dispose of the drug that you no longer need. These measures are aimed for the protection of the environment.

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